Cerebral Folate Deficiency Syndromes in Childhood
نویسندگان
چکیده
منابع مشابه
Cerebral folate deficiency syndromes in childhood: clinical, analytical, and etiologic aspects.
BACKGROUND Cerebral folate deficiency may be amenable to therapeutic supplementation. Diverse metabolic pathways and unrelated processes can lead to cerebrospinal fluid 5-methyltetrahydrofolate (5-MTHF) depletion, the hallmark of cerebral folate deficiency. OBJECTIVE To analyze cerebral folate abundance in a large prospective series of children diagnosed with any neurologic disorder for which...
متن کاملClinical recognition and aspects of the cerebral folate deficiency syndromes.
We characterized cerebral folate deficiency (CFD) as any neuro-psychiatric condition associated with low spinal fluid (CSF) N5-methyltetrahydrofolate (MTHF) but normal folate status outside the central nervous system (CNS). The commonest cause underlying CFD syndromes is the presence of serum autoantibodies of the blocking type directed against folate receptor-α (FRα) attached to the plasma-sid...
متن کاملCerebral folate deficiency syndrome.
to the editor: Ramaekers et al. (May 12 issue)1 report 28 patients with the cerebral folate deficiency syndrome characterized by decreased levels of 5-methyltetrahydrofolate (5MTHF) in the cerebrospinal fluid caused by autoantibodies’ blocking of folate transport into the brain. The patients benefited from folinic acid supplementation. The clinical features of this syndrome fit with other neuro...
متن کاملCerebral folate deficiency.
Cerebral folate deficiency (CFD) can be defined as any neurological syndrome associated with low cerebrospinal fluid (CSF) 5-methyltetrahydrofolate (5MTHF), the active folate metabolite, in the presence of normal folate metabolism outside the nervous system. CFD could result from either disturbed folate transport or from increased folate turnover within the central nervous system (CNS). We repo...
متن کاملAdult-onset cerebral folate deficiency.
OBJECTIVE To report new manifestations of cerebral folate deficiency, a rare metabolic autoimmune syndrome,in an adult. DESIGN Case report. SETTING University teaching hospital. PATIENT A 58-year-old woman with progressive memory loss and myoclonus presented for medical attention. Results of cerebral spinal fluid analysis showed low levels of tetrahydrobiopterin and 5-methyltetrahydrofola...
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ژورنال
عنوان ژورنال: Archives of Neurology
سال: 2011
ISSN: 0003-9942
DOI: 10.1001/archneurol.2011.80